Genome Analysis of a Historical Shigella dysenteriae Serotype 1 Strain Carrying a Conserved Stx Prophage Region

Shigella dysenteriae are significant agents of bacillary dysentery, accounting for a considerable number illnesses with high morbidity worldwide. The Shiga toxin (Stx) encoded by defective prophage is the key virulence factor S. type 1 (SD1) strains. Here we present full genome sequence an SD1 strain HNCMB 20080 isolated in 1954, compare it to other sequenced genomes, and assess diversity Stx-prophages harbored previously consists chromosome sized 4,393,622 bp containing 5,183 CDSs, as well two small plasmids. Comparative genomic analysis revealed degree uniformity among including structure Stx regions, which found form subgroups termed PT-I PT-II. All strains members (ST) 146 or ST260, while only PT-II harboring strain, Sd1617 proved be ST untypeable. In accordance data from previous reports, Stx1 could not induced 20080. Our cumulative do support notion that stx -harboring phages STEC derived historical isolates.